From Solvent–Solute to Protein–Drug Interactions: Application of a New Theory in Chemistry
1. Introduction Molecular interactions underpin the stability and reactivity of chemical and biological systems. In classical chemistry, solvent–solute interactions have been explained by dielectric constants, hydrophobicity, and hydrogen bonding principles. In biochemistry, protein–drug interactions are governed by more complex forces such as van der Waals contacts, π–π stacking, and conformational …