Development of a Water-Soluble Phosphorodiamidate Prodrug of Salicylic Acid
Introduction Salicylic acid (SA) is a commonly used drug with therapeutic applications as an analgesic, antipyretic, and anti-inflammatory agent. However, its low aqueous solubility (~0.2 mg/mL) limits its bioavailability and clinical utility. Enhancing solubility is therefore a crucial goal in improving its formulation and pharmacokinetics. The prodrug approach is a …