Introduction Metolazone is a thiazide-like diuretic commonly marketed under brand names such as Zytanix, Metoz, Zaroxolyn, and Mykrox. It is primarily indicated for the management of congestive heart failure (CHF) and hypertension. The drug exerts its diuretic effect by reducing the reabsorption of water in the kidneys, thereby decreasing blood …
Introduction Drug delivery to the central nervous system (CNS) remains a major hurdle due to the restrictive nature of the blood-brain barrier (BBB). Traditional systemic administration often results in poor drug penetration into the brain, necessitating alternative strategies. Intranasal drug delivery has gained attention as a direct route to the …
Introduction Plastics have fundamentally transformed modern life, offering lightweight, durable, and versatile solutions across industries. However, the heavy reliance on petroleum-derived plastics has caused severe environmental consequences due to their persistence and accumulation in ecosystems [1]. Addressing this global issue necessitates sustainable alternatives. Bioplastics, sourced from renewable feedstocks, offer a …
Medicinal plants have long been integral to human health, serving as treatments for various ailments worldwide. Plants are prolific sources of bioactive compounds, making them valuable for developing new medicines. Pongamia pinnata Linn. Pierre (Fabaceae), known as karanj or poonga oil tree, is a medium-sized, fast-growing leguminous tree, mainly native …
Alzheimer disease is a neurodegenerative disease of memory loss. It is the most common cause of dementia like decline in memory, thinking, behavior and social skills (1). Alzheimer’s disease gradually affects other regions of the brain, including those responsible for basic physiological activities like walking and swallowing. This is because …
