The study investigates the spectral and electrochemical properties of various fenamate non-steroidal anti-inflammatory drugs (NSAIDs), namely fenamic, mefenamic, meclofenamic, flufenamic, and tolfenamic acids, as well as their copper(II) complexes in a 1:2 molar ratio (metal:ligand) in dimethyl sulfoxide (DMSO). Cyclic voltammetry (CV) was employed to examine the redox behavior of the complexes, revealing notable similarities in the cyclic voltammograms of the fenamate ligands and their corresponding copper (II) complexes. Electrochemical analysis showed a significant shift in the reduction potential (Epc) towards less negative values and the oxidation peak potential (Epa) becoming more negative upon complexation with copper(II), indicating that reduction becomes more facile upon metal coordination. These observations confirm the electroactive nature of the copper(II) fenamate complexes. Additionally, electronic absorption and mass spectroscopic studies were conducted to further characterize the spectral properties of the fenamate ligands and their copper complexes. This investigation highlights the unique redox behavior of copper(II) fenamate complexes, offering insights into their potential applications in catalysis and drug delivery systems.