Abstract for Post: Synthesis and Characterization of a Water-Soluble Salicylic Acid Phosphorodiamidate

Author(s): Dr. Manisha Rathore , Dr. Ramesh Bhargaw
Affiliation: Rajiv Gandhi Institute of Pharmacy, Faculty of Pharmaceutical Science & Technology, AKS University, Satna, Madhya Pradesh, India
Corresponding Email: manisharathor987@rediffmail.com

Salicylic acid (SA) is a widely used therapeutic agent with anti-inflammatory and analgesic properties, but its limited solubility in water restricts its bioavailability. In this study, a water-soluble phosphorodiamidate prodrug of salicylic acid was designed and synthesized to overcome solubility limitations. The prodrug was characterized using spectroscopic and analytical techniques including ^1H NMR, ^31P NMR, FT-IR, UV-Vis spectroscopy, and elemental analysis. The water solubility of the prodrug was found to be significantly enhanced compared to native salicylic acid. The structural confirmation and purity assessment suggest potential applications in pharmaceutical formulations for improved delivery and therapeutic efficacy.