The present study focuses on the rational design and development of cocrystals composed of Naproxen (NPX) and Paracetamol (PCM) to enhance solubility, thermal stability, and formulation performance. Cocrystallization was achieved using solvent evaporation and neat grinding techniques in varying molar ratios. The resultant cocrystals were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Powder X-Ray Diffraction (PXRD), and Scanning Electron Microscopy (SEM). Solubility, dissolution rate, and stability studies were conducted to evaluate improvements over the pure drugs. The optimized 1:1 Naproxen–Paracetamol cocrystal exhibited a 2.3-fold increase in aqueous solubility, improved dissolution efficiency, and enhanced physical stability under accelerated conditions. The study highlights the potential of pharmaceutical cocrystallization as a green and rational approach to modulate physicochemical and biopharmaceutical properties of poorly soluble drugs