This study investigates the synthesis, characterization, and antimicrobial activities of a series of azo-Schiff base ligands and their corresponding metal(II) complexes. The ligands were synthesized by the condensation of aromatic amines with carbonyl compounds, followed by complexation with metal ions such as Cu(II), Co(II), Ni(II), Zn(II), and Mn(II). The antimicrobial activities were evaluated against various bacterial and fungal strains using standard disc diffusion methods. The results indicated that the metal complexes exhibited enhanced antimicrobial properties compared to the free ligands, suggesting the potential application of these complexes as antimicrobial agents.