The increasing contamination of water bodies with hexavalent chromium (Cr(VI)) necessitates the exploration of cost-effective and efficient remediation methods. Luffa cylindrica, a natural biosorbent, has garnered attention for its potential in Cr(VI) removal. This review synthesizes studies from 2010 to 2020, focusing on the biosorption capacity, kinetics, isotherms, and thermodynamics of Cr(VI) onto L. cylindrica. The findings highlight its effectiveness, with adsorption capacities ranging from 5.91 to 29.98 mg/g, and suggest that the process is spontaneous and exothermic.