Homocysteine(Hcy) may promote atherogenesis through oxidativestress. Malondialdehyde (MDA), which produced through peroxidation of lipid. It is widely used in estimating the oxidative stress.  We aimed to evaluate the serum Hcy levelsand serum MAD in   atherosclerosis patients and to find whether these variables are associated with the severity of atherosclerosis disease. Sixty patients diagnosed with atherosclerosis diseases were included in our study. Patients were divided to three groups(Low risk= 1.0, moderate risk = 3.55, and high risk= > 6.15) according to the value of atherogenic index.Fifteenhealthy individual, as control group.Serum MDA is estimated by methods of  Benge ( 1978). Hcywere quantitatively determined in patients and control subjects by means of competitive ELISA test using commercially available kits.The receiver operator curve (ROC) analysis of the forthcoming variations revealed the descending order of ( Hcy = 0.959; MAD = 0.832;TC = 0.609;  LDL = 0.594;and  Tri = 0.502) that showed significant variation. The rest of parameters (uric acid, HDL and albumine) failed to occupy a significant ROC area.In our study,we found serum each Hcy and MAD was significantly increased in patients than control; it was gradually increased with increase atherogenic index, affected by the severity of disease, and significantly increases in third group than first group of patients. Person linear correlation revealed a significant positive linear correlation with serum Hcy and MAD and increased risk factor of atherosclerosis disease in the three progressed groups of patients. In summary, there is a significant relation between Hcy levels, MDA, and atherosclerosis diseases. These conclusions promote the hypothesis that the opposing effect of oxidative stress on the atherosclerosis diseases might be mediated by Hcy. This relationship could cause early development of atherosclerosis diseases even in males. So we suggest that Hcy and MAD might be taken into consideration through the evaluation of atherosclerosis patients