Malaria is a serious infectious disease caused by Plasmodium parasites that infect red blood cells. Antimalarial treatment often involves the use of drug combinations like piperaquine phosphate, which disrupts the parasite’s heme metabolism. These medications are rapidly absorbed, reaching peak concentrations within 3–5 hours. Malaria accounts for more than a million deaths annually, particularly in Africa where drug resistance complicates therapy. Although there is no vaccine, traditional plant-based medicines continue to show promise in the development of effective new treatments.