The effects of aqueous leaves extracts of Telfeiria occidentalis and Talinum triangulare on haematological parameters in albino rats were studied using Auto Haematology Analyzer by Mindray BC 2800. Twenty (20) albino rats were randomly distributed into four (4) groups of five (5) rats each. Group 1 served as control and received only standard feed and water, group 2 received 250 mg/Kg of aqueous leaf extract of T. Occidentalis, group 3 received 250 mg/Kg of T. triangulare and group 4 received 250 mg/Kg mixture of T. occidentalis and T. triangulare of 1:1 weight by weight for 21 days. Administration of the extracts were done orally. At the end of the treatment period, haematological parameters such as white blood cell count, red blood cell count, platelet count, haematocrit, haemoglobin concentration, mean corpuscle volume, mean corpuscle haemoglobin and mean corpuscle haemoglobin concentration were determined. The results showed no significant change (p>0.05) in all haematological parameters except white blood cell count (p<0.05) in group 2, 3 and 4 as compared to the control group. In conclusion, the results of the study shows that, the leaf extract of T. Occidentalis and T. Triangulare administered through the period of this study has positive effect only on the white blood cell count, there was no increase on the other Haematological parameters (RBC, PCV, Hb Conc. and platelet) in the treated rats when compared with the control group (p>0.05).