Thiazolidinone is a biologically important five-membered heterocyclic ring with almost all biological activities. Recent advances in the biological activities reported for 4-thiazolidinone derivatives, such as peroxisome proliferator-activated receptors y binders, and antioxidants, anti-tuberculosis have been covered in this review.  it includes the method of synthesis of thiazolidinone.it is synthesized by grindstone technology as a facile method. it mainly involves the green chemistry synthesis approach. Novel Thiazolidinone derivative is synthesized by simple synthesis of imines through nucleophilic acyl substitution reaction which involves a reaction between aniline and benzaldehyde in the presence of catalyst natural acid. The compound formed is treated with thioglycolic acid and 1,2 -dioxane stirring the reaction at temperature 600C for 4hrs to give thiazolidinones. The obtained thiazolidinones undergone conventional synthesis is refluxed for 12hrs to give the title compound. Thiazolidinone is screened for antidiabetic activity by in vitro glucose uptake assay using Pioglitazone as standard. The synthesized compound showed  a very good potent activity towards anti-diabetic properties compared with standard pioglitazone drugs. thiazolidinones are the class of oral agents for the treatment of type – 2 diabetes, improving insulin sensitivity and lowering blood glucose, free fatty acid, and triglycerides levels. The thiazolidinones are PPARR-y (peroxisome proliferative-activated receptors ) agonists.