This review presents a systematic and comprehensive survey of the methods of preparation of triazine derivatives. These compounds are important intermediates for the synthesis of a variety and novel heterocyclic systems. The triazines are  extremely  significant classes of organic compounds that triazine nucleus used as chemotherapeutic agents due to their motivating pharmacological properties such as antimicrobial, antituberculosis, antiviral, antiprotozoal, antimalarial, anticancer. The derivatives of s-triazines are originated to possess precious antimicrobial activity against various bacterial and fungal species. The constant spread of life threatening transmittable diseases further undergo  the urgent requirement to find novel, safe and more potent compounds to maintain and improve the managing and  prevention of such diseases in a new age of serious disease control, elimination and eradication. This review of triazine derivatives provides the basis for the design of biologically significant molecules with extensive application as therapeutics.